Department of Radiotherapy and Oncology is one of the major clinical departments in Hospital Sultan Ismail. It was established as a leading referral centre for cancer treatment for Southern Region especially in Johor.
The department was then known as the Oncology Treatment Center and has started its first service by taking Sultanah Aminah Hospital, Oncology Clinic in 2005, which previously conducted by Kuala Lumpur Hospital.
The first Oncology Clinic, Hospital Sultan Ismail, was started on 5th September 2006, accompanied by the use of Day Care Unit (Daycare) for the treatment of chemotherapy as an outpatient. Service development was followed by the opening of the oncology ward, 6D on October 9, 2006 to implement chemotherapy as inpatient treatmet.
Radiotherapy service has started on May 14, 2007 together with the opening ward 6C to accommodate patients for radiotherapy who live outside of Johor Bahru. In August 2009, brachytherapy treatment was started with the treatment of cases of Cervical Cancer (Ca. Cervix), Uterine Cancer (Ca. Uterus) and Cancer Nasofarink ( Nasopharingeal Ca.).